Trifluoroacetic acid methylene chloride → HCID 57613219, compound

HRID 910688Notes

Reaction equation

HRID 910688 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([C:20]3[S:21][CH:22]=[CH:23][CH:24]=3)[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[N:11]1([C:14]2[CH:19]=[C:18]([C:20]3[S:21][CH:22]=[CH:23][CH:24]=3)[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 67388409HCID 67388409, compound

Product 1

HCID 57613219HCID 57613219, compound

Procedure

A solution of 4-(6-thiophen-2-yl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (30 mg, 0.08 mmol) in 1:1 TFA/CH2Cl2 (3 mL) was stirred for 2 h, and then was concentrated to yield the title compound, as its corresponding TFA salt.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-645eeda479f344969a8010b97f9d820d
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

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