HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine | HCID 1714225 | — |
Reaction Steps
To a solution of 2,4-dichloropyrimidine (447 mg, 3 mmol) in ethanol (10 mL) was added 1-methylpyperazine (360 mg, 3.6 mmol). The resulting mixture was stirred at room temperature overnight. The resulting white solid was collected by filtration and washed with ethanol, Na2CO3 solution and water and ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022209B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-5aa3ce636099429b85a813584cc09145 |
| Source note | uspto-grants-2011_09 |