1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

HRID 910690Notes

Reaction equation

HRID 910690 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>C(O)C>[Cl:1][C:2]1[N:7]=[C:6]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 775312,4-Dichloropyrimidine

Product 1

HCID 17142252-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2,4-dichloropyrimidine (447 mg, 3 mmol) in ethanol (10 mL) was added 1-methylpyperazine (360 mg, 3.6 mmol). The resulting mixture was stirred at room temperature overnight. The resulting white solid was collected by filtration and washed with ethanol, Na2CO3 solution and water and ethanol.

Workup

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed with ethanol, Na2CO3 solution and water and ethanol

Sources & evidence

ORD record
ord-5aa3ce636099429b85a813584cc09145
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

Loading…