1-Methylpiperazine → 2-Chloro-4-(3-chloro-thiophen-2-yl)-6-(4-methyl-piperazin-1-yl)-pyrimidine

Participants

Reaction Steps

To a vial was added 2,4-dichloro-6-(3-chloro-thiophen-2-yl)-pyrimidine (50 mg, 0.19 mmol), 1-methylpiperazine (50 mg, 0.5 mmol), and ethanol (2 mL). The resulting mixture was stirred at room temperature for 3 hrs. Ethanol was removed and the resulting residue was dissolved with EtOAc. The organic layer was washed with 1N hydrochloric acid and concentrated to yield the title compound as a solid.

Provenance & Evidence