反应详情

To a vial was added 2,4-dichloro-6-(3-chloro-thiophen-2-yl)-pyrimidine (50 mg, 0.19 mmol), 1-methylpiperazine (50 mg, 0.5 mmol), and ethanol (2 mL). The resulting mixture was stirred at room temperature for 3 hrs. Ethanol was removed and the resulting residue was dissolved with EtOAc. The organic layer was washed with 1N hydrochloric acid and concentrated to yield the title compound as a solid.

1. customEthanol was removed
2. dissolutionthe resulting residue was dissolved with EtOAc
3. washThe organic layer was washed with 1N hydrochloric acid
4. concentrationconcentrated