2-Chloro-4-(3-chloro-thiophen-2-yl)-6-(4-methyl-piperazin-1-yl)-pyrimidine → 2-Chloro-4-(4-methyl-piperazin-1-yl)-6-thiophen-2-yl-pyrimidine

HRID 910706Notes

Reaction equation

HRID 910706 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:9][CH:10]=[CH:11][C:12]=2Cl)[CH:5]=[C:4]([N:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[N:3]=1>CO.[Pd]>[Cl:1][C:2]1[N:3]=[C:4]([N:14]2[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]2)[CH:5]=[C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

4

Reactant 1

HCID 576132142-Chloro-4-(3-chloro-thiophen-2-yl)-6-(4-methyl-piperazin-1-yl)-pyrimidine

Product 1

HCID 105657792-Chloro-4-(4-methyl-piperazin-1-yl)-6-thiophen-2-yl-pyrimidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-chloro-4-(3-chloro-thiophen-2-yl)-6-(4-methyl-piperazin-1-yl)-pyrimidine (30 mg, 0.1 mmol) in methanol (2 mL) was added 10% Pd/C (15 mg). The resulting mixture was stirred under hydrogen balloon overnight. Palladium on carbon was removed through Celite® filtration. The filtrate was dried and purified by TLC plate to yield the title compound as a solid.

Workup

  1. customPalladium on carbon was removed through Celite® filtration
  2. customThe filtrate was dried
  3. custompurified by TLC plate

Sources & evidence

ORD record
ord-65577cb7f79e44a2a6b51b9a4e35c32b
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

Loading…