2-Chloro-4-(3-chloro-thiophen-2-yl)-6-(4-methyl-piperazin-1-yl)-pyrimidine → 2-Chloro-4-(4-methyl-piperazin-1-yl)-6-thiophen-2-yl-pyrimidine

Participants

Reaction Steps

To a solution of 2-chloro-4-(3-chloro-thiophen-2-yl)-6-(4-methyl-piperazin-1-yl)-pyrimidine (30 mg, 0.1 mmol) in methanol (2 mL) was added 10% Pd/C (15 mg). The resulting mixture was stirred under hydrogen balloon overnight. Palladium on carbon was removed through Celite® filtration. The filtrate was dried and purified by TLC plate to yield the title compound as a solid.

Provenance & Evidence