HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 910743Generated: November 2, 2026
Potassium Carbonate → 3-Bromo-5-ethoxy-4-[(3-nitrobenzyl)oxy]benzaldehyde
https://huagongshe.com/reaction/910743
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzene, 1-(bromomethyl)-3-nitro- | HCID 77568 | — |
| Reactant | 3-Bromo-5-ethoxy-4-hydroxybenzaldehyde | HCID 612496 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Bromo-5-ethoxy-4-[(3-nitrobenzyl)oxy]benzaldehyde | HCID 585840 | — |
Reaction Steps
A mixture of 3-nitrobenzylbromide (2 g), 3-bromo-5-ethoxy-4-hydroxy benzaldehyde (2.06 g), K2CO3 (2.55 g) and Bu4NI (186 mg) in DMF (50 ml) was stirred at 60° C. for 2 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was recrystallized from heptane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08022218B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-cfb5c841b89a46d88744f1c574ef5d07 |
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| Source note | uspto-grants-2011_09 |
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