Methyl 3-(bromomethyl)benzoate → 3-(2-Bromo-6-ethoxy-4-formylphenoxymethyl)-benzoic acid methyl ester

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Reaction Steps

Alkylation of 3-bromo-5-ethoxy-4-hydroxy benzaldehyde (2 g) with 3-bromomethyl-benzoic acid methyl ester (2.06 g) was performed according to the method described in example 1a. The residue was chromatographed on silica gel in heptane/ethyl acetate=7/3 (v/v) as eluent. Yield: 2.42 g. MS-ESI: [M+H]+=393/395

Provenance & Evidence