Dichloromethane → HCID 10607830, compound

HRID 910756Notes

Reaction equation

HRID 910756 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].CC[N:8]([CH:12]([CH3:14])[CH3:13])[CH:9]([CH3:11])C.[Cl:15]CCl>>[Cl:15][CH2:14][C:12]1[N:8]([S:2]([CH3:1])(=[O:4])=[O:3])[CH:9]=[CH:11][CH:13]=1

Participants

4

Reactant 3

HCID 6344Dichloromethane2×HCID 31297Methanesulfonyl chlorideHCID 81531Diisopropylethylamine

Product 1

HCID 10607830HCID 10607830, compound

Procedure

At 0° C. methanesulfonyl chloride (136 μl) was added dropwise to a solution of the product of example 51b (205 mg) and DIPEA (307 μl) in dichloromethane (6 ml). After stirring for 30 min, the reaction mixture was diluted with dichloromethane (30 ml) and washed with ice water (30 ml), 10% HCl (30 ml) and sat. NaHCO3. The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo. Yield: 252 mg.

Workup

  1. washwashed with ice water (30 ml), 10% HCl (30 ml) and sat. NaHCO3
  2. customThe organic layer was separated
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-d5225a0cfb56414195f3a3b8b559c0f5
Source dataset
uspto-grants-2011_09
Patent number
US08022218B2

Reaction notes

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