HCID 67061780, compound → HCID 86651707, compound

HRID 910800Notes

Reaction equation

HRID 910800 reaction equation
[CH3:1][O:2][CH2:3][C@H:4]([CH3:49])[CH2:5][O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C@@H:14]2[C@@H:19]([O:20][CH2:21][C:22]3[CH:23]=[CH:24][C:25]4[O:30][CH2:29][CH2:28][N:27]([CH2:31][CH2:32][CH2:33][O:34][CH3:35])[C:26]=4[CH:36]=3)[CH2:18][N:17]([S:37]([C:40]3[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=3)(=[O:39])=[O:38])[C@H:16]([CH2:47][OH:48])[CH2:15]2)=[CH:10][CH:9]=1>CCOC(C)=O.CCCCCCC>[CH3:1][O:2][CH2:3][C@H:4]([CH3:49])[CH2:5][O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C@@H:14]2[C@@H:19]([O:20][CH2:21][C:22]3[CH:23]=[CH:24][C:25]4[O:30][CH2:29][CH2:28][N:27]([CH2:31][CH2:32][CH2:33][O:34][CH3:35])[C:26]=4[CH:36]=3)[CH2:18][N:17]([S:37]([C:40]3[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=3)(=[O:38])=[O:39])[C@H:16]([CH2:47][O:48][S:37]([CH3:40])(=[O:39])=[O:38])[CH2:15]2)=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 67061780HCID 67061780, compound

Product 1

HCID 86651707HCID 86651707, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound is prepared according to general procedure F starting from 1.0 mmol of [(2S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-methanol. Rf=0.45 (EtOAc/heptane 2:1); Rt=5.52 (gradient I).

Sources & evidence

ORD record
ord-2747c0d7e4944d8fb6d857ff2d6a8375
Source dataset
uspto-grants-2011_09
Patent number
US08022068B2

Reaction notes

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