HCID 67061749, compound → HCID 67061875, compound

HRID 910814Notes

Reaction equation

HRID 910814 reaction equation
C(OC(=O)[NH:10][CH2:11][C@H:12]1[CH2:17][C@H:16]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][O:25][CH2:26][C@@H:27]([CH3:31])[CH2:28][O:29][CH3:30])=[CH:20][CH:19]=2)[C@@H:15]([O:32][CH2:33][C:34]2[CH:35]=[CH:36][C:37]3[O:42][CH2:41][CH2:40][N:39]([CH2:43][CH2:44][CH2:45][O:46][CH3:47])[C:38]=3[CH:48]=2)[CH2:14][N:13]1[S:49]([C:52]1[CH:57]=[CH:56][C:55]([CH3:58])=[CH:54][CH:53]=1)(=[O:51])=[O:50])C1C=CC=CC=1>CO>[CH3:30][O:29][CH2:28][C@H:27]([CH3:31])[CH2:26][O:25][CH2:24][C:21]1[CH:22]=[CH:23][C:18]([C@@H:16]2[C@@H:15]([O:32][CH2:33][C:34]3[CH:35]=[CH:36][C:37]4[O:42][CH2:41][CH2:40][N:39]([CH2:43][CH2:44][CH2:45][O:46][CH3:47])[C:38]=4[CH:48]=3)[CH2:14][N:13]([S:49]([C:52]3[CH:57]=[CH:56][C:55]([CH3:58])=[CH:54][CH:53]=3)(=[O:50])=[O:51])[C@@H:12]([CH2:11][NH2:10])[CH2:17]2)=[CH:19][CH:20]=1

Participants

3

Reactant 1

HCID 67061749HCID 67061749, compound

Product 1

HCID 67061875HCID 67061875, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to general procedure E, 1 mmol of [(2R,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-ylmethyl]-carbamic acid benzyl ester is reacted in MeOH, to afford the title compound as a yellow oil. Rf=0.1 (CH2Cl2/MeOH/25% conc. NH3 200:10:1); Rt=4.62 (gradient I).

Sources & evidence

ORD record
ord-0066694127434243a0eced43ef9dcf1d
Source dataset
uspto-grants-2011_09
Patent number
US08022068B2

Reaction notes

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