反应详情

18-(p-Iodophenyl)octadecyl acetate 42 (1.55 g, 3.01 mmol) was dissolved in THF (10 ml), MeOH (5 ml) and solution of NaOH (240 mg, 6.03 mmol) in H2O (1 ml) was added. The reaction mixture was stirred at room temperature for 2 h, quenched with aqueous NaHCO3 solution and extracted with EtOAc. Extract was dried over Na2SO4 and evaporated. Silica gel chromatography in hexane-EtOAc (95:5, 90:10) gave the product, 1.36 g (95%).

1. customquenched with aqueous NaHCO3 solution
2. extractionextracted with EtOAc
3. extractionExtract
4. dry with materialwas dried over Na2SO4
5. customevaporated
6. customSilica gel chromatography in hexane-EtOAc (95:5, 90:10) gave the product, 1.36 g (95%)