Sodium borohydride → HCID 67392158, compound

HRID 910824Notes

Reaction equation

HRID 910824 reaction equation
[CH:1]([C:3]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:4]=1[O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])=[O:2].[BH4-].[Na+]>C(O)C>[OH:2][CH2:1][C:3]1[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:14][C:4]=1[O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86620099HCID 86620099, compound

Product 1

HCID 67392158HCID 67392158, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from step (i) (2.0 g) was dissolved in dry ethanol (20 ml) then sodium borohydride (0.15 g) added. The mixture was stirred at RT overnight then evaporated under reduced pressure to give a white solid. The solid was partitioned between 2M hydrochloric acid and ethylacetate, the organics were dried and evaporated under reduced pressure, yield 0.70 g.

Workup

  1. customthen evaporated under reduced pressure
  2. customto give a white solid
  3. customThe solid was partitioned between 2M hydrochloric acid and ethylacetate
  4. customthe organics were dried
  5. customevaporated under reduced pressure, yield 0.70 g

Sources & evidence

ORD record
ord-3392e6ee92784ba4980a11c75a86e6d1
Source dataset
uspto-grants-2011_09
Patent number
US08022248B2

Reaction notes

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