Sodium Hydroxide → [(4-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]thio}phenyl)thio]acetic acid

Participants

Reaction Steps

A mixture of the product from step (iv) (0.10 g), sodium hydroxide (0.018 g) in methanol (5 ml) and water (5 ml) was stirred at RT for 1 h. The mixture was partitioned between 2M hydrochloric acid/ethyl acetate, the organics separated, dried and evaporated under reduced pressure. The residue was purified by reverse phase HPLC. Yield 0.012 g

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