Benzyl Bromide → 2-(Benzyloxy)-4-fluorobenzaldehyde

Participants

Reaction Conditions

Reaction Steps

A mixture of the product from step (i) (3.0 g), potassium carbonate (4.42 g) and benzyl bromide (3.90 ml) in DMF (40 ml) was heated at 90° C. for 14 h. The mixture was partitioned between water/ethyl acetate, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/diethylether 5:1, yield 6.3 g.

Provenance & Evidence