Sodium Bicarbonate → HCID 131729187, compound

HRID 910846Notes

Reaction equation

HRID 910846 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:4]([O:15][C:16]2[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:18][C:17]=2[Cl:26])[CH:3]=1.[C:27](=O)([O-])O.[Na+]>COS(OC)(=O)=O.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH3:27])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:4]([O:15][C:16]2[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:23])=[O:24])=[CH:18][C:17]=2[Cl:26])[CH:3]=1

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 131729188HCID 131729188, compound

Product 1

HCID 131729187HCID 131729187, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6497Dimethyl SulfateSolvent

Procedure

The subtitle compound was prepared by using the product from example 15 step ii). (0.70 g) which was dissolved in dimethylsulphate (3 ml). Sodium hydrogen carbonate (0.355 g) was added and heated to 90 C for 2 hours. The mixture was diluted with water, extracted with ethyl acetate, dried, and concentrated under reduced pressure to give an oil. The residue was purified by chromatography on silica eluting with diethyl ether, yield 0.70 g.

Workup

  1. temperatureheated to 90 C for 2 hours
  2. extractionextracted with ethyl acetate
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customto give an oil
  6. customThe residue was purified by chromatography on silica eluting with diethyl ether, yield 0.70 g

Sources & evidence

ORD record
ord-4f30aa27647b408e861eb84d4bb5132e
Source dataset
uspto-grants-2011_09
Patent number
US08022248B2

Reaction notes

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