Methanol → HCID 11653774, compound

HRID 910865Notes

Reaction equation

HRID 910865 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12]CC)=[O:11])=[C:4]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[C:18]([Cl:26])[CH:17]=2)[CH:3]=1.CO.[OH-].[Na+]>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[C:4]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:23])([F:25])[F:24])=[C:18]([Cl:26])[CH:17]=2)[CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 67392144HCID 67392144, compound

Product 1

HCID 11653774HCID 11653774, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of the product from step (ii) (0.5 g), methanol (5 ml), water (4 ml) and 2M NaOH (2 ml) were stirred at room temperature for 4 h then partitioned between ethylacetate/2 M HCl. The organics were separated, washed with water, dried and evaporated under reduced pressure. The residue was triturated with diethylether/isohexane and filtered, yield 0.1 g.

Workup

  1. customthen partitioned between ethylacetate/2 M HCl
  2. customThe organics were separated
  3. washwashed with water
  4. customdried
  5. customevaporated under reduced pressure
  6. customThe residue was triturated with diethylether/isohexane
  7. filtrationfiltered

Sources & evidence

ORD record
ord-764c98fdd8074a7782011fdb988b60c7
Source dataset
uspto-grants-2011_09
Patent number
US08022248B2

Reaction notes

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