ethyl (2E)-3-(4-chloro-2-nitrophenyl)prop-2-enoate → 7-Chloro-1,2,3,4-tetrahydroquinolin-2-one

Participants

Reaction Steps

A mixture of the product from step (i) (4.95 g) and 5% platinum on carbon (0.400 g) and a few drops of 2M hydrochloric acid in ethyl acetate (30 ml) was hydrogenated under a pressure of 3 bar. The catalyst was removed by filtration through celite and the filtrate was evaporated under reduced pressure to a brown solid, which was triturated with diethyl ether to give a pink solid. Yield 1.28 g

Provenance & Evidence