HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4-Chloro-2-hydroxyphenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-(4-Chloro-2-methoxyphenyl)acetic acid | HCID 14675568 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Chloro-2-hydroxyphenylacetic acid | HCID 133825 | — |
Reaction Steps
4-chloro-2-methoxy-benzeneacetic acid (1.4 g), HBr (25 ml), acetic acid (5 ml) were refluxed for 48 h then evaporated under reduced pressure. The residue was azeotroped with toluene and triturated with diethyl ether and isohexane. Yield 0.56 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022248B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-aec44375af674c33840c44931fe1fa8a |
| Source note | uspto-grants-2011_09 |