反应详情

4-chloro-2-methoxy-benzeneacetic acid (1.4 g), HBr (25 ml), acetic acid (5 ml) were refluxed for 48 h then evaporated under reduced pressure. The residue was azeotroped with toluene and triturated with diethyl ether and isohexane. Yield 0.56 g.

1. customthen evaporated under reduced pressure
2. customThe residue was azeotroped with toluene
3. customtriturated with diethyl ether and isohexane