反应详情

Using the method of Example 3, Step B, 4-isopropylthiazol-2-amine (0.245 g, 1.72 mmol), 2-chloro-4-(2,6-dichlorophenylthio)pyridine (0.500 g, 1.72 mmol), potassium phosphate (0.402 g, 1.89 mmol), Pd2(dba)3 (0.079 g, 0.086 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.050 g, 0.086 mmol) were reacted to provide N-(4-(2,6-dichlorophenylthio)pyridin-2-yl)-4-isopropylthiazol-2-amine (0.260 g, 38% yield) as a white powder. 1H NMR (d6-DMSO) δ 11.07 (s, 1H), 8.10 (d, 1H), 7.76 (d, 2H), 7.64 (t, 1H), 6.57 (s, 1H), 6.56 (d, 1H), 6.51 (s, 1H), 2.82 (hextet, 1H), 1.18 (d, 6H).

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