HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 911011Generated: October 31, 2026
Potassium Phosphate, Tribasic → HCID 24826753, compound
https://huagongshe.com/reaction/911011
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 86634744 | HCID 86634744 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 24826753 | HCID 24826753 | — |
Reaction Steps
A mixture of 2,6-dichloro-4-(2,6-difluorophenoxy)pyridine (552 mg, 2.0 mmol), 4-methylthiazol-2-amine (228 mg, 2.0 mmol), potassium phosphate (466 mg, 2.20 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.092 g, 0.100 mmol) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.167 g, 0.100 mmol) in degassed toluene (5 mL) and water (2 mL) is heated at 90° C. for 12 hours and then cooled to room temperature. The reaction mixture is partitioned between water and ethyl acetate to afford N-(6-chloro-4-(2,6-difluorophenoxy)pyridin-2-yl)-4-methylthiazol-2-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08022222B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-b5efb411b2e84158933c9db49f8b64d1 |
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| Source note | uspto-grants-2011_09 |
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