Sodium Hydroxide → HCID 86634746, compound

HRID 911013Notes

Reaction equation

HRID 911013 reaction equation
[Br:1][C:2]1[C:3]([O:20][C:21]2[C:26]([F:27])=[CH:25][CH:24]=[CH:23][C:22]=2[F:28])=[CH:4][C:5]([NH:8][C:9]([NH:11]C(=O)C2C=CC=CC=2)=[S:10])=[N:6][CH:7]=1.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:3]([O:20][C:21]2[C:22]([F:28])=[CH:23][CH:24]=[CH:25][C:26]=2[F:27])=[CH:4][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86634745HCID 86634745, compound

Product 1

HCID 86634746HCID 86634746, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-(5-bromo-4-(2,6-difluorophenoxy)pyridin-2-ylcarbamothioyl)benzamide (4.41 g, 9.5 mmol) and 3M NaOH (10 ml, 30 mmol) in ethanol (40 mL) is heated. The reaction mixture is cooled, concentrated to 15 mL, diluted with water, and filtered to afford 1-(5-bromo-4-(2,6-difluorophenoxy)pyridin-2-yl)thiourea.

Workup

  1. temperatureis heated
  2. temperatureThe reaction mixture is cooled
  3. concentrationconcentrated to 15 mL
  4. additiondiluted with water
  5. filtrationfiltered

Sources & evidence

ORD record
ord-b45974d111d9402484c86921c9387f10
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

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