Benzoyl isothiocyanate → HCID 86634747, compound

HRID 911016Notes

Reaction equation

HRID 911016 reaction equation
[C:1]([N:9]=[C:10]=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:12][C:13]1[C:14]([O:21][C:22]2[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=2[F:29])=[C:15]([Cl:20])[C:16]([NH2:19])=[N:17][CH:18]=1>ClCCl>[Br:12][C:13]1[C:14]([O:21][C:22]2[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=2[F:29])=[C:15]([Cl:20])[C:16]([NH:19][C:10]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[S:11])=[N:17][CH:18]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 66617807HCID 66617807, compound

Product 1

HCID 86634747HCID 86634747, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Benzoyl isothiocyanate (163 mg, 1.0 mmol) is added to a solution of 5-bromo-3-chloro-4-(2,6-difluorophenoxy)pyridin-2-amine (336 mg, 1.0 mmol) in dichloromethane (20 mL) at 0° C. The reaction mixture is warmed to room temperature and stirred for one hour. The reaction mixture is diluted with hexanes and filtered to afford N-(5-bromo-3-chloro-4-(2,6-difluorophenoxy)pyridin-2-ylcarbamothioyl)benzamide.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-c2037f6294e6430eb8deb26cec9048c4
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

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