Sodium Hydroxide → HCID 86634748, compound

HRID 911017Notes

Reaction equation

HRID 911017 reaction equation
[Br:1][C:2]1[C:3]([O:21][C:22]2[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=2[F:29])=[C:4]([Cl:20])[C:5]([NH:8][C:9]([NH:11]C(=O)C2C=CC=CC=2)=[S:10])=[N:6][CH:7]=1.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:3]([O:21][C:22]2[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=2[F:29])=[C:4]([Cl:20])[C:5]([NH:8][C:9]([NH2:11])=[S:10])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86634747HCID 86634747, compound

Product 1

HCID 86634748HCID 86634748, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-(5-bromo-3-chloro-4-(2,6-difluorophenoxy)pyridin-2-ylcarbamothioyl)benzamide (474 mg, 0.95 mmol) and 3M NaOH (1 mL, 30 mmol) in ethanol (4 mL) is heated. The reaction mixture is cooled, concentrated to 2 mL, diluted with water, and filtered to afford 1-(5-bromo-3-chloro-4-(2,6-difluorophenoxy)pyridin-2-yl)thiourea.

Workup

  1. temperatureis heated
  2. temperatureThe reaction mixture is cooled
  3. concentrationconcentrated to 2 mL
  4. additiondiluted with water
  5. filtrationfiltered

Sources & evidence

ORD record
ord-2a77b28a9ec84f689632175b21eb427a
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

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