HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Ethyl 4-chloro-3-(2-chloropyridin-4-yloxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-4-nitropyridine | HCID 735152 | — |
| Reactant | Ethyl 4-chloro-3-hydroxybenzoate | HCID 58847555 | — |
| Product | Ethyl 4-chloro-3-(2-chloropyridin-4-yloxy)benzoate | HCID 86634737 | 53% |
Reaction Steps
Following the method of Example 3, Step A, ethyl 4-chloro-3-hydroxybenzoate (5.75 g, 28.7 mmol), sodium hydride (0.724 g, 28.7 mmol), DM (30 mL), and 2-chloro-4-nitropyridine (4.54 g, 28.7 mmol) were combined to give the desired product (4.75 g, 47.8% yield) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022222B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-62f3a5404044455bbd14b7f7284840d0 |
| Source note | uspto-grants-2011_09 |