1-Ethylpiperazine → HCID 86634757, compound

HRID 911033Notes

Reaction equation

[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].[ClH:9].[CH3:10][C:11]1[N:12]=[C:13]([NH:16][C:17]2[CH:25]=[C:24]([O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:20]([C:21](O)=[O:22])=[CH:19][N:18]=2)[S:14][CH:15]=1>>[ClH:9].[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:21]([C:20]2[CH:19]=[N:18][C:17]([NH:16][C:13]3[S:14][CH:15]=[C:11]([CH3:10])[N:12]=3)=[CH:25][C:24]=2[O:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[O:22])[CH2:5][CH2:4]1)[CH3:2]

Participants

Reactant 2

HCID 791961-Ethylpiperazine

HCID 24826423HCID 24826423, compound

Product 1

HCID 86634757HCID 86634757, compound

Procedure

Prepared according to the method of Example 32 from 1-ethylpiperazine and 6-(4-methylthiazol-2-ylamino)-4-phenoxynicotinic acid hydrochloride (Example 59). Yield: 0.055 g, 43.07%. 1H NMR (CDCl3) δ 8.34 (s, 1H), 7.47 (t, 2H), 7.33 (t, 1H), 7.06 (s, 1H), 7.04 (s, 1H), 6.38 (s, 1H), 6.26 (s, 1H), 3.97 (m, 3H), 2.97 (m, 7H), 2.27 (s, 3H), 1.46 (t, 3H).

Workup

customPrepared

Sources & evidence

ORD record: ord-aebcccbb5ad148c29bacee91dd9db363
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08022222B2

Reaction notes

Loading…