HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 911038Generated: October 31, 2026
Triethylamine → ethyl 3-(5-bromo-2-(4-phenethylthiazol-2-ylamino)-Pyridin-4-yloxy)-4-chlorobenzoate
https://huagongshe.com/reaction/911038
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Bromo-4-phenylbutan-2-one | HCID 12608027 | — |
| Reactant | Ethyl 3-(5-bromo-2-thioureidopyridin-4-yloxy)-4-chlorobenzoate | HCID 86634759 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 3-(5-bromo-2-(4-phenethylthiazol-2-ylamino)-Pyridin-4-yloxy)-4-chlorobenzoate | HCID 57898948 | 96.4% |
Reaction Steps
A flask was charged with ethyl 3-(5-bromo-2-thioureidopyridin-4-yloxy)-4-chlorobenzoate (0.200 g, 0.464 mmol), 1-bromo-4-phenylbutan-2-one (0.105 g, 0.464 mmol) and triethylamine (0.0470 g, 0.464 mmol). Ethanol (5 mL) was added and the reaction was heated at 70° C. for 6 hours, and then concentrated to provide ethyl the desired product (0.250 g, 95 yield) as white solid. LC/MS (apci) M+2H: 560 (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08022222B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-1d01b8808b54441bbb5743dd3cf3c68f |
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| Source note | uspto-grants-2011_09 |
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