Potassium Carbonate → HCID 86634784, compound

HRID 911073Notes

Reaction equation

HRID 911073 reaction equation
C([NH:9][C:10](=[S:25])[NH:11][C:12]1[CH:17]=[C:16]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:15]([Br:24])=[CH:14][N:13]=1)(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Br:24][C:15]1[C:16]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][C:12]([NH:11][C:10]([NH2:9])=[S:25])=[N:13][CH:14]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86634783HCID 86634783, compound

Product 1

HCID 86634784HCID 86634784, compoundYield 99.54%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

A flask was charged with ethyl 2-(2-(3-benzoylthioureido)-5-bromopyridin-4-yl)acetate (2.940 g, 6.962 mmol) and ethanol (100 mL), and potassium carbonate (4.811 g, 34.81 mmol) was added. The mixture was heated at 70° C. for 2 hours, then filtered hot. The filter cake was washed with a small amount of ethanol, and the filtrate was concentrated to provide the desired product (2.205 g, 99.54%) as a yellow solid.

Workup

  1. additionwas added
  2. filtrationfiltered hot
  3. washThe filter cake was washed with a small amount of ethanol
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-5e8ae1432b854e048ff4ebf60abd1f5d
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

Loading…