3-Isopropylphenol → HCID 17861092, compound

HRID 911257Notes

Reaction equation

HRID 911257 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH:10]([C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1)([CH3:12])[CH3:11]>>[CH:10]([C:13]1[CH:14]=[C:15]([CH:16]=[CH:17][CH:18]=1)[O:19][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1)([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 120593-IsopropylphenolHCID 12162Benzonitrile, 4-bromo-

Product 1

HCID 17861092HCID 17861092, compoundYield 33%

Procedure

Use a method similar to Preparation 32 (Step 1), using 4-bromobenzonitrile (2.0 g, 11.3 mmol) and 3-isopropylphenol (3.08 g, 22.6 mmol) to give 4-(3′-isopropylphenoxy)-benzonitrile (885 mg, 33%). MS (ES+) m/z: 255 (M+NH4)+.

Workup

  1. customsimilar to Preparation 32 (Step 1)

Sources & evidence

ORD record
ord-ca69ae16114c46d0a6b770cdd29893cd
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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