Piperidine → 1-[4-(piperidin-1-ylcarbonyl)phenyl]methanamine

HRID 911292Notes

Reaction equation

HRID 911292 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OC([NH:14][CH2:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1)=O)(C)(C)C>>[N:1]1([C:20]([C:19]2[CH:23]=[CH:24][C:16]([CH2:15][NH2:14])=[CH:17][CH:18]=2)=[O:21])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 8536054-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid

Product 1

HCID 71312631-[4-(piperidin-1-ylcarbonyl)phenyl]methanamineYield 100%

Procedure

Use the General Procedure 6-1, using piperidine (373 mg, 4.4 mmol) and 4-(tert-butoxycabonylamino-methyl)-benzoic acid to give the title compound as a white solid (1.03 g, 100%). MS (ES+) m/z: 219 (M+H)+.

Sources & evidence

ORD record
ord-9f0741cb45724ccd8574b7073618e86b
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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