Hydrochloric Acid → HCID 12270050, compound

HRID 911326Notes

Reaction equation

HRID 911326 reaction equation
[CH:1]1([C:7]#[N:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]([OH:11])[CH3:10].[ClH:12]>O1CCOCC1>[ClH:12].[CH2:9]([O:11][C:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)=[NH:8])[CH3:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 69834Cyanocyclohexane

Product 1

HCID 12270050HCID 12270050, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Combine cyclohexanecarbonitrile (1.0 g, 9.20 mmol), ethanol (0.4 g, 9.20 mmol) and 4N hydrogen chloride in dioxane (8 mL) and stir the reaction mixture for 17 h at ambient temperature. Evaporate the solvent and triturate the residue with diethyl ether to obtain the desired intermediate as a white solid (1.4 g, 80%).

Workup

  1. customEvaporate the solvent
  2. customtriturate the residue with diethyl ether

Sources & evidence

ORD record
ord-1e1a333cb9234364ab95a53964fb22f0
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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