反应详情

To a stirred solution of (2-methanesulfonyl-phenyl)methanol (735 mg, 3.99 mmol) in dry DCM (2 mL) at 0° C., add a solution of 1M phosphorous tribromide in DCM (6.0 mL, 6.0 mmol) and continue stirring for 1 h. Dilute with saturated aqueous NaHCO3, extract three times with ethyl ether, dry over anhydrous MgSO4 and concentrate in vacuo. Purify by chromatography on silica gel eluting with hexane/EtOAc (12:1) to provide the title compound as a white solid (950 mg, 97%).

1. extractionextract three times with ethyl ether
2. dry with materialdry over anhydrous MgSO4
3. concentrationconcentrate in vacuo
4. customPurify by chromatography on silica gel eluting with hexane/EtOAc (12:1)