3-(Bromomethyl)-6-chloropyridazine → HCID 19040625, compound

HRID 911477Notes

Reaction equation

HRID 911477 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15](SC(=O)N(C)C)=[C:16](Cl)[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.BrCC1N=NC(Cl)=CC=1>>[CH2:13]1[C:12]2[CH:15]=[CH:16][CH:17]=[CH:18][C:11]=2[CH:10]=[CH:9][N:8]=[CH:14]1

Participants

3

Reactant 2

HCID 230809253-(Bromomethyl)-6-chloropyridazineHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 19040625HCID 19040625, compound

Procedure

Use a method similar to the Preparation 177, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 3-bromomethyl-6-chloropyridazine to give 3-tert-butoxycarbonyl-7-chloro-6-(6-chloro-pyridazin-3-ylmethylthio)-2,3,4,5-tetrahydro)-1H-benzo[d]azepine. Use a method similar to the General Procedure 14 to give the title compound as an off-white powder. MS (APCI+) m/z: 340 (M+H)+.

Workup

  1. customsimilar to the Preparation 177

Sources & evidence

ORD record
ord-62c678f9c7254a75a34bab832e882256
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

Loading…