2-(Chloromethyl)-6-methoxypyridine--hydrogen chloride (1/1) → HCID 66706891, compound

HRID 911489Notes

Reaction equation

HRID 911489 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.ClC[C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[N:30]=1>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[N:30]=1

Participants

3

Reactant 2

HCID 545930112-(Chloromethyl)-6-methoxypyridine--hydrogen chloride (1/1)HCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66706891HCID 66706891, compound

Procedure

Use a method similar to the Example 330, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2-chloromethyl-6-methoxypyridine hydrochloride to give, after deprotection by a method similar to the General Procedure 14, the title compound as a white solid (120 mg). MS (APCI+) m/z: 335 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-f973790b05244d68ab8acd540245f2a9
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

Loading…