Azepane → HCID 67382219, compound

HRID 911497Notes

Reaction equation

HRID 911497 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][S:9][C:10]2[C:20]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15][C:14]=3[CH:13]=[CH:12][C:11]=2[Cl:28])=[N:6][CH:7]=1.[NH:29]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1>>[ClH:28].[N:29]1([C:2]2[CH:3]=[CH:4][C:5]([CH2:8][S:9][C:10]3[C:20]4[CH2:19][CH2:18][NH:17][CH2:16][CH2:15][C:14]=4[CH:13]=[CH:12][C:11]=3[Cl:28])=[N:6][CH:7]=2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 8119AzepaneHCID 576562493-tert-butoxycarbonyl-6-(5-bromopyridin-2-ylmethylthio)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 67382219HCID 67382219, compound

Procedure

Use a method similar to the Example 369, using 6-(5-bromopyridin-2-ylmethylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H benzo[d]azepine and homopiperidine to give the title compound as a yellow solid. MS (ES+) m/z 402 (M+H)+.

Sources & evidence

ORD record
ord-55bcef39e4c74f62b9e0ebec2f9324b9
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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