Piperidine → HCID 66706915, compound

HRID 911498Notes

Reaction equation

HRID 911498 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][CH2:21][C:22]3[CH:23]=[N:24][C:25](Cl)=[CH:26][CH:27]=3)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.[NH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([N:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)=[N:24][CH:23]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 86629659HCID 86629659, compound

Product 1

HCID 66706915HCID 66706915, compound

Procedure

Use a method similar to the Example 369, using 3-tert-butoxycarbonyl-7-chloro-6-(6-chloropyridin-3-ylmethylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine and piperidine, to give the title compound as a white solid. MS (ES+) m/z: 388 (M+H)+.

Sources & evidence

ORD record
ord-329fe62b2b4d4de3ba90c0bb5b467962
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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