Methyl 4-bromobutyrate → HCID 66706705, compound

HRID 911538Notes

Reaction equation

HRID 911538 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.BrC[CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31]>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31]

Participants

3

Reactant 2

HCID 107604Methyl 4-bromobutyrateHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66706705HCID 66706705, compound

Procedure

Use a method similar to the Example 347, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and methyl 4-bromobutyrate to give, after deprotection by the General Procedure 1-4, the title compound as a white solid. MS (ES+) m/z: 314 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-8dc96e978b034b52ad3db8cc848981e7
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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