反应详情

Heat a mixture of 3,3,4′-trimethylbutyrophenone (2 g, 10.52 mmol), NBS (2.061 g, 11.57 mmol), and AIBN (43 mg, 0.263 mmol) in carbon tetrachloride (60 mL) for 14 h at reflux. Cool the reaction, mixture to ambient temperature and wash sequentially with water, 1M aqueous HCl, 5% aqueous NaHCO3 and brine. Concentrate the organic layer in vacuo to provide the desired intermediate as oil (2.54 g, 90%) that was used without any further purification.

1. temperatureHeat
2. temperatureat reflux
3. temperatureCool
4. customthe reaction, mixture to ambient temperature
5. washwash sequentially with water, 1M aqueous HCl, 5% aqueous NaHCO3 and brine
6. concentrationConcentrate the organic layer in vacuo