2,2-Difluoro-2-(2-pyridyl)ethyl trifluoromethanesulfonate → 7-Chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride

Participants

Reaction Steps

Example 647 may be prepared essentially as described in Example 646 using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2,2-difluoro-2-pyridin-2-yl-ethyl trifluoromethanesulfonate (prepared by following the procedure described in J. Med. Chem. 2003, 46, 461-473) (66% yield, MS (ES+) m/z 355 (M+H)+).

Provenance & Evidence