Sodium Hydroxide → 1-(5-Bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea

HRID 911808Notes

Reaction equation

HRID 911808 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[C:18]([O:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)=[CH:17][C:16]([Br:27])=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>>[Br:27][C:16]1[CH:17]=[C:18]([O:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 866314841-Benzoyl-3-(5-bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea

Product 1

HCID 866314851-(5-Bromo-3-(4-fluorophenoxy)pyridin-2-yl)thioureaYield 84.3%

Procedure

Following the procedure in Example 7, Step D, 1-benzoyl-3-(5-bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea (1150 mg, 2.58 mmol) and 3M sodium hydroxide (1.7 mL, 5.1 mmol) provided 1-(5-bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea (743 mg, 84.3% yield) as a white solid.

Sources & evidence

ORD record
ord-c4c48a208803495fae759a50c12d6599
Source dataset
uspto-grants-2011_09
Patent number
US08022223B2

Reaction notes

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