HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(5-Bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Benzoyl-3-(5-bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea | HCID 86631484 | — |
| Product | 1-(5-Bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea | HCID 86631485 | 84.3% |
Reaction Steps
Following the procedure in Example 7, Step D, 1-benzoyl-3-(5-bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea (1150 mg, 2.58 mmol) and 3M sodium hydroxide (1.7 mL, 5.1 mmol) provided 1-(5-bromo-3-(4-fluorophenoxy)pyridin-2-yl)thiourea (743 mg, 84.3% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022223B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-c4c48a208803495fae759a50c12d6599 |
| Source note | uspto-grants-2011_09 |