Propanal → HCID 66995125, Verbindung

HRID 911821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 911821
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=O)=[C:5]([CH3:10])[O:4][N:3]=1.N1CC[CH2:14][CH2:13][CH2:12]1.C(=O)CC>CCO>[CH3:1][C:2]1[C:6]2=[N+:7]([O-:9])[C:13]([CH3:14])=[CH:12][CH:10]=[C:5]2[O:4][N:3]=1

Komponenten

5

Edukt 3

HCID 527PropanalHCID 8082PiperidineHCID 2614103,5-Dimethyl-4-nitroisoxazole

Produkt 1

HCID 66995125HCID 66995125, VerbindungAusbeute 225 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customchromatographed

Quellen und Nachweise

ORD-Eintrag
ord-a9d4ad6753aa4fba9ae239735904992f
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022223B2

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