反应详情

温度

-78 °C

Placed tert-butyl 4-formylpiperidine-1-carboxylate (2.00 g, 9.38 mmol) in THF (40 mL) and cooled to −78° C. Slowly added methylmagnesium bromide (3.44 mL, 10.3 mmol) stirred for 1 hour. Slowly added saturated ammonium chloride and extracted with CH2Cl2. Concentrated and redissolved in 5% MeOH in CH2Cl2. Added ether and filtered off solids. Concentrate filtrate to give the title compound (1.94 g, 90.2% yield)

1. extractionSlowly added saturated ammonium chloride and extracted with CH2Cl2
2. concentrationConcentrated
3. dissolutionredissolved in 5% MeOH in CH2Cl2
4. filtrationAdded ether and filtered off solids