Hydrochloric Acid → 2-(Cyanomethyl)benzoic acid

HRID 912040ノート

反応式

HRID 912040 の反応式
[C:1]([CH2:3][C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7])#[N:2].[OH-].[Na+].Cl>>[C:1]([CH2:3][C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7])#[N:2]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 588805Methyl 2-(cyanomethyl)benzoate

生成物 1

HCID 811142-(Cyanomethyl)benzoic acid

反応条件

温度
40 °C

実験手順

A mixture of methyl 2-cyanomethylbenzoate (10.5 g, 60.0 mmol) in aq. NaOH (66 mL, 66 mmol, 1N solution) was heated at 40° C. for 5 h and it became a clear solution. The mixture was cooled to 0° C. and acidified to pH 1 using 6N aq. HCl. The resulting white solid was collected by filtration. 1H NMR (CD3OD): δ=4.27 (s, 2H), 7.46 (td, J=7.8, 1.0 Hz, 1H), 7.54-7.60 (m, 2H), 8.09 (dd, J=7.8, 1.3 Hz, 1H).

後処理

  1. temperatureThe mixture was cooled to 0° C.
  2. filtrationThe resulting white solid was collected by filtration

出典と根拠

ORDレコード
ord-32afde55692d4ea08e5d496ec87cb243
出典データセット
uspto-grants-2011_09
特許番号
US08022206B2

反応ノート

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