4-(Trifluoromethoxy)aniline → HCID 59244508, compound

HRID 912088Notes

Reaction equation

HRID 912088 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.FC(F)(F)OC1C=CC(N)=CC=1.C[O:38][C:39]1[CH:40]=[C:41]([C:45]2[C:46]3[CH2:59][CH2:58][N:57]([C:60]4[CH:65]=[CH:64][C:63]([O:66][C:67]([F:70])([F:69])[F:68])=[CH:62][CH:61]=4)[C:47]=3[N:48]=[C:49]([N:51]3[CH2:56][CH2:55][O:54][CH2:53][CH2:52]3)[N:50]=2)[CH:42]=[CH:43][CH:44]=1>>[N:51]1([C:49]2[N:50]=[C:45]([C:41]3[CH:40]=[C:39]([OH:38])[CH:44]=[CH:43][CH:42]=3)[C:46]3[CH2:59][CH2:58][N:57]([C:60]4[CH:65]=[CH:64][C:63]([O:66][C:67]([F:70])([F:69])[F:68])=[CH:62][CH:61]=4)[C:47]=3[N:48]=2)[CH2:52][CH2:53][O:54][CH2:55][CH2:56]1

Participants

4

Reactant 3

HCID 6008484-(Trifluoromethoxy)anilineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67385473HCID 67385473, compound

Product 1

HCID 59244508HCID 59244508, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 4-trifluoromethoxyaniline, 4-(3-methoxy-phenyl)-2-morpholin-4-yl-7-(4-trifluoromethoxy-phenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-6510e9377dd442318e763c4701c5358a
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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