4-Isopropylaniline → HCID 24889263, compound

HRID 912092Notes

Reaction equation

HRID 912092 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.C(C1C=CC(N)=CC=1)(C)C.[CH:35]([C:38]1[CH:43]=[CH:42][C:41]([N:44]2[C:48]3[N:49]=[C:50]([N:61]4[CH2:66][CH2:65][O:64][CH2:63][CH2:62]4)[N:51]=[C:52]([C:53]4[CH:58]=[CH:57][CH:56]=[C:55]([O:59]C)[CH:54]=4)[C:47]=3[CH2:46][CH2:45]2)=[CH:40][CH:39]=1)([CH3:37])[CH3:36]>>[CH:35]([C:38]1[CH:39]=[CH:40][C:41]([N:44]2[C:48]3[N:49]=[C:50]([N:61]4[CH2:66][CH2:65][O:64][CH2:63][CH2:62]4)[N:51]=[C:52]([C:53]4[CH:54]=[C:55]([OH:59])[CH:56]=[CH:57][CH:58]=4)[C:47]=3[CH2:46][CH2:45]2)=[CH:42][CH:43]=1)([CH3:37])[CH3:36]

Participants

4

Reactant 3

HCID 74644-IsopropylanilineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67386072HCID 67386072, compound

Product 1

HCID 24889263HCID 24889263, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 4-isopropylaniline, 7-(4-isopropyl-phenyl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-0db336886dbd4e75b742a9a0221b0a58
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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