4-Aminopyridine → HCID 59244961, compound

HRID 912096Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Cl[C:9]1[N:14]=[C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:12]=[C:11]([C:21]2[CH:22]=[C:23]([S:27]([NH:30][CH3:31])(=[O:29])=[O:28])[CH:24]=[CH:25][CH:26]=2)[C:10]=1[CH2:32][CH2:33]Cl>>[CH3:31][NH:30][S:27]([C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([C:11]2[C:10]3[CH2:32][CH2:33][N:1]([C:2]4[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=4)[C:9]=3[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[N:12]=2)[CH:22]=1)(=[O:29])=[O:28]

Participants

Reactant 2

HCID 17274-Aminopyridine

HCID 71520969HCID 71520969, compound

Product 1

HCID 59244961HCID 59244961, compound

Procedure

Using 4-aminopyridine instead of 3-aminopyridine, and 3-[6-chloro-5-(2-chloro-ethyl)-2-morpholin-4-yl-pyrimidin-4-yl]-N-methyl-benzenesulfonamide instead of 4-[4-chloro-5-(2-chloro-ethyl)-6-phenyl-pyrimidin-2-yl]-morpholine, in the same manner as Example 1-A-37, the desired compound was obtained as a yellow solid (yield 9%).

Sources & evidence

ORD record: ord-c76326e6732940c0a228ce2dc8b28fad
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08022205B2

Reaction notes

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