2-Aminothiazole → HCID 24889765, compound

HRID 912103Notes

Reaction equation

HRID 912103 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.NC1SC=CN=1.C[O:32][C:33]1[CH:34]=[C:35]([C:39]2[C:40]3[CH2:53][CH2:52][N:51]([C:54]4[S:55][CH:56]=[CH:57][N:58]=4)[C:41]=3[N:42]=[C:43]([N:45]3[CH2:50][CH2:49][O:48][CH2:47][CH2:46]3)[N:44]=2)[CH:36]=[CH:37][CH:38]=1>>[N:45]1([C:43]2[N:44]=[C:39]([C:35]3[CH:34]=[C:33]([OH:32])[CH:38]=[CH:37][CH:36]=3)[C:40]3[CH2:53][CH2:52][N:51]([C:54]4[S:55][CH:56]=[CH:57][N:58]=4)[C:41]=3[N:42]=2)[CH2:50][CH2:49][O:48][CH2:47][CH2:46]1

Participants

4

Reactant 3

HCID 21552-AminothiazoleHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67386637HCID 67386637, compound

Product 1

HCID 24889765HCID 24889765, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2-aminothiazole, 4-(3-methoxy-phenyl)-7-(thiazol-2-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-bb7e74b103eb41b98a6afea391f45f1e
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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